Related Experiment Video

Updated: Aug 18, 2026

Fluorescent End-Labeling and Encapsulation of Long RNAs for Single-Molecule FRET-TIRF Microscopy
10:59

Fluorescent End-Labeling and Encapsulation of Long RNAs for Single-Molecule FRET-TIRF Microscopy

Published on: October 18, 2024

A new class of Spiegelmers containing 2'-fluoro-nucleotides

S Helmling1, E Moyroud, W Schroeder

  • 1NOXXON Pharma AG, Berlin, Germany.

Nucleosides, Nucleotides & Nucleic Acids
|October 21, 2003
PubMed

Abstract:

Synthesis of 2'-fluoro-nucleosides from L-arabinose in order to perform the synthesis of 2'-fluoro-Spiegelmers binding to a neuropeptide.

More Related Videos

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
05:37

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Published on: April 4, 2025

Split Hybridization Probe Utilizing a DNA Fluorescent Light-up Aptamer as a Signal Reporter for Sequence-Specific Nucleic Acid Analysis
07:10

Split Hybridization Probe Utilizing a DNA Fluorescent Light-up Aptamer as a Signal Reporter for Sequence-Specific Nucleic Acid Analysis

Published on: July 8, 2025

Related Experiment Videos

Last Updated: Aug 18, 2026

Fluorescent End-Labeling and Encapsulation of Long RNAs for Single-Molecule FRET-TIRF Microscopy
10:59

Fluorescent End-Labeling and Encapsulation of Long RNAs for Single-Molecule FRET-TIRF Microscopy

Published on: October 18, 2024

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
05:37

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Published on: April 4, 2025

Split Hybridization Probe Utilizing a DNA Fluorescent Light-up Aptamer as a Signal Reporter for Sequence-Specific Nucleic Acid Analysis
07:10

Split Hybridization Probe Utilizing a DNA Fluorescent Light-up Aptamer as a Signal Reporter for Sequence-Specific Nucleic Acid Analysis

Published on: July 8, 2025

Related Concept Videos

FISH - Fluorescent In-situ Hybridization02:07

FISH - Fluorescent In-situ Hybridization

Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...
Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...

Articles linked to this work by shared authors, journal, and citation graph.

The use of Fisher's exact test in contingency table analysis in palaeopathology.

International journal of paleopathology·2026

What makes physicians implement climate change and heat adaptation measures in outpatient practices? A mixed-methods study.

Public health·2025

Which types of bony changes in the maxillary sinus indicate chronic sinusitis?

International journal of paleopathology·2024

Environmental drivers of increased ecosystem respiration in a warming tundra.

Nature·2024

Immersion of debrided diabetic foot ulcer tissue in electrochemically generated pH neutral hypochlorous acid significantly reduces the microbial bioburden: whole-genome sequencing of Staphylococcus aureus, the most prevalent species recovered.

The Journal of hospital infection·2023

Combined regression score predicts outcome after neoadjuvant treatment of oesophageal cancer.

British journal of cancer·2023

Synthesis, cytotoxicity, and antimicrobial activity of triphenylphosphonium (TPP) conjugates of 1,2,3-triazolyl analogues of pyrimidine nucleosides bearing N-acetyl-β-D-glucosamine residue.

Nucleosides, nucleotides & nucleic acids·2026

Study on the role of miR-433-3p in the occurrence and development of endometriosis.

Nucleosides, nucleotides & nucleic acids·2026

LncRNA APTR as a potential prognostic biomarker for triple-negative breast cancer.

Nucleosides, nucleotides & nucleic acids·2026

Cation- and sequence length-dependent kinetics for B-/Z-DNA transition.

Nucleosides, nucleotides & nucleic acids·2026

Nucleoterpenoids consisting of isosteviol and uridine. Synthesis and cytotoxicity evaluation.

Nucleosides, nucleotides & nucleic acids·2026

Synergistic MgSiO3 nanocatalysis for the efficient synthesis of benzo[d]oxazol-2-yl phenylisoxazoles: structural elucidation, drug-likeness profiling, and target-oriented biomolecular interactions.

Nucleosides, nucleotides & nucleic acids·2026

Safety and Effectiveness of Placental Connective Tissue Matrix Allograft Versus Corticosteroid Injection in Adhesive Capsulitis: A Double-Blinded Prospective Randomized Study.

JB & JS open access·2026

Beyond ADCs: Antibody-encapsulated drug for targeted cancer therapy.

Cell investigation·2026

The structural language of fungal cell wall sugars in WHO priority fungi: the determinant of pathogenicity and the gateway to new therapies.

Frontiers in immunology·2026

Extraction of Amylases from Insects for Testing Inhibitory Compounds from Plants.

Methods in molecular biology (Clifton, N.J.)·2026

Interaction between Hovenia dulcis polysaccharides and dihydromyricetin: A systematic study on structure, in vitro digestion, and functionality.

Food research international (Ottawa, Ont.)·2026

Thermodynamic and structural insights into sodium caseinate - Quinine binding interactions and their effect on bitterness perception.

Food research international (Ottawa, Ont.)·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us