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Improved synthesis of 2'-amino-LNA
Signe M Christensen1, Christoph Rosenbohm, Mads Sørensen
1Cureon A/S, Copenhagen, Denmark. smc@cureon.com
Nucleosides, Nucleotides & Nucleic Acids
|October 21, 2003
Abstract:
2'-Amino-LNA phosphoramidite (10) was synthesised by means of a new strategy, which is convergent with the synthesis of 2'-oxy-LNA up until a late stage intermediate (1).
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