Synthesis and hybridization properties of oligodeoxynucleotides containing 3'-deoxy-3'-C-methyleneuridine
Dorthe Lindegaard1, Jesper Wengel
1Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Odense M, Denmark.
Nucleosides, Nucleotides & Nucleic Acids
|October 21, 2003
Abstract:
3'-Deoxy-3'-C-methyleneuridine nucleoside 1 has been incorporated into oligodeoxynucleotides. Relative to the unmodified references, oligomers containing nucleoside 1 displayed reduced binding affinities towards complementary DNA and RNA with a tendency towards RNA-selective hybridization.
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