Related Experiment Videos
Towards a DNA-like duplex without hydrogen bonds
Gérald Mathis1, Rolf Schütz, Jürg Hunziker
1Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland. gerald.mathis@ioc.unibe.ch
Nucleosides, Nucleotides & Nucleic Acids
|October 21, 2003
Abstract:
The inverse quadrupolar moments of the phenyl and pentafluorophenyl residues in the base pair P-F5 promotes strong intramolecular stacking interactions in DNA duplexes. The more natural base pairs are replaced by this novel pair the higher the thermodynamic stability of the resulting duplex if they are arranged in an alternating fashion.