Related Experiment Video
Updated: Aug 30, 2026
08:38
Targeted DNA Methylation Analysis by Next-generation Sequencing
Published on: February 24, 2015
Methylated hexitol nucleic acids, towards congeners with improved antisense potential
A Van Aerschot1, A Marchand, G Schepers
1Laboratory for Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium. arthur.vanaerschot@rega.kuleuven.ac.be
Nucleosides, Nucleotides & Nucleic Acids
|October 21, 2003
Abstract:
In an effort to further improve the hybridisation potential of anhydro-hexitol nucleoside analogues, the 1'-methoxyl and 3'-methoxyl substituents were introduced and evaluated for their antisense potential. In view of the selectivity of pairing with RNA, especially the introduction of a 3'-O-alkyl moiety deserves further study.
