Preparation of 6-thioguanosine phosphoramidite for oligoribonucleotide synthesis
Yang Wang1, Eric Lattmann, Qinguo Zheng
1School of Life and Health Sciences, Aston University, Birmingham, England.
Nucleosides, Nucleotides & Nucleic Acids
|October 21, 2003
Abstract:
6-Thioguanosine phosphoramidite was prepared, using 2,4-dinitrophenyl as protection group for thio-function, and its stability towards conditions of RNA synthesis was investigated. The results show that the monomer was stable under the conditions of RNA synthesis and suitable for incorporation of thioguanine into oligoribonucleotides.
