Imidazolethyl-phosphoramidate alpha-oligonucleotides
1Laboratoire de Chimie Organique Biomoléculaire de Synthèse, Université de Montpellier II, UMR 5625 CNRS-UMII, Montpellier, France.
Nucleosides, Nucleotides & Nucleic Acids
|October 21, 2003
Abstract:
Alpha-ODNs conjugated to imidazole groups via phosphoramidate internucleosidic linkages were synthesized. The presence of the imidazolethyl-phosphoramidate linkage improved the affinity of alpha-ODNs for their nucleic acid targets.
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