Related Experiment Videos
Synthesis of 2'-spiro ribo- and arabinonucleosides
B Ravindra Babu1, Lise Keinicke, Jesper Wengel
1Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Odense M, Denmark.
Nucleosides, Nucleotides & Nucleic Acids
|October 21, 2003
Abstract:
Four conformationally restricted bicyclic 2'-spiro nucleosides were synthesised and incorporated into oligonucleotides. These spiro nucleotides induced decreased duplex thermostabilities.