Related Experiment Video
Updated: Aug 30, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
A novel PNA-monomer for recognition of thymine in triple-helix structures
Anne Goldbech Olsen1, Otto Dahl, Peter E Nielsen
1Department of Chemistry, University of Copenhagen, Copenhagen O, Denmark. ago@kiku.edu
Abstract:
To expand the triplex recognition repertoire of Nucleic Acids, novel nucleobases that recognize thymine in a T-A base pair are still required. A novel conformationally constrained PNA-monomer (II) capable of binding T in a triplex motif was designed and synthesized in 7 steps starting from commercially available dimethyl 2-oxoglutarate.
Related Concept Videos
DNA Base Pairing
The DNA Helix
The DNA Helix
Nucleic Acid Structure
DNA Structure
DNA has a double-helix structure. The...
Proofreading
Proofreading
Errors During Replication are Corrected by the DNA Polymerase Enzyme

