The use of triisopropylsilyl-oxymethyl (TOM) in the synthesis of anti-telomerase 2-5A antisense compound RBI 011
Hagen Cramer1, Rachele Rhea, Jim Okicki
1Ridgeway Biosystems Inc., Cleveland, Ohio, USA.
Nucleosides, Nucleotides & Nucleic Acids
|October 21, 2003
Abstract:
The 2-5A antisense compound RBI 011 targeting telomerase RNA was synthesized using the triisopropylsilyl-oxymethyl (TOM) group for the 3'-hydroxyl protection of 2',5'-linked RNA.


