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Updated: Aug 30, 2026
Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
Published on: May 30, 2011
Comparison of arterial spin-labeling techniques and dynamic susceptibility-weighted contrast-enhanced MRI in
Marc-André Weber1, Matthias Günther, Matthias P Lichy
1Division Radiological Diagnostics and Therapy, German Cancer Research Center, Heidelberg, Germany. m.a.weber@dkfz.de
Objectives:
To evaluate relative cerebral blood flow (rCBF) in normal brain tissue using arterial spin-labeling (ASL) methods and first-pass dynamic susceptibility-weighted contrast-enhanced (DSC) magnetic resonance imaging (MRI).
Methods:
Sixty-two patients with brain metastases were examined on a 1.5 T-system up to 6 times during routine follow-up after stereotactic radiosurgery. Perfusion values in normal gray and white matter were measured using the ASL techniques ITS-FAIR in 38 patients, Q2TIPS in 62 patients, and the first-pass DSC echo-planar (EPI) MRI after bolus administration of gadopentetate dimeglumine in 42 patients. Precision of the ASL sequences was tested in follow-up examinations in 10 healthy volunteers.
Results:
Perfusion values in normal brain tissue obtained by all sequences correlated well by calculating Pearson's correlation coefficients (P < 0.0001) and remained unchanged after stereotactic radiosurgery as shown by analysis of variance (P > 0.05).
Conclusion:
Both ASL and DSC EPI MRI yield highly comparable perfusion values in normal brain tissue.
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