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Updated: Aug 18, 2026

A Cost-effective and Reliable Method to Predict Mechanical Stress in Single-use and Standard Pumps
Published on: August 5, 2015
Performance prediction of industrial centrifuges using scale-down models
M Boychyn1, S S S Yim, M Bulmer
1The Advanced Centre for Biochemical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK.
Abstract:
Computational fluid dynamics was used to model the high flow forces found in the feed zone of a multichamber-bowl centrifuge and reproduce these in a small, high-speed rotating disc device. Linking the device to scale-down centrifugation, permitted good estimation of the performance of various continuous-flow centrifuges (disc stack, multichamber bowl, CARR Powerfuge) for shear-sensitive protein precipitates. Critically, the ultra scale-down centrifugation process proved to be a much more accurate predictor of production multichamber-bowl performance than was the pilot centrifuge.
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