Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nerve remodelling during intestinal inflammation.

R H Stead1

  • 1Department of Pathology, McMaster University, Hamilton, Ontario, Canada.

Annals of the New York Academy of Sciences
|January 1, 1992
PubMed
Summary

Intestinal nerves remodel during nematode infection, showing structural plasticity. This nerve plasticity in inflamed tissues impacts interactions between the enteric nervous system and mucosal elements during disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activation of the cannabinoid 2 (CB2) receptor inhibits murine mesenteric afferent nerve activity.

Neurogastroenterology and motility·2007
Same author

The mast cell-nerve axis in wound healing: a hypothesis.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society·1998
Same author

Choline acetyltransferase (ChAT) immunoreactivity in paraffin sections of normal and diseased intestines.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society·1998
Same author

Vagal afferent nerve fibres contact mast cells in rat small intestinal mucosa.

Neuroimmunomodulation·1998
Same author

Studies of multimerin in human endothelial cells.

Blood·1998
Same author

Mast cell Fc epsilonRI expression in the rat intestinal mucosa and tongue is enhanced during Nippostrongylus brasiliensis infection and can be up-regulated by in vivo administration of IgE.

Journal of immunology (Baltimore, Md. : 1950)·1997

Area of Science:

  • Gastroenterology
  • Neuroscience
  • Immunology

Background:

  • The intestinal mucosa has a complex nerve network and inflammatory cells.
  • Mast cells in the intestinal mucosa are innervated and change density during nematode infection.
  • Nerve remodeling occurs in the rat jejunum after Nippostrongylus brasiliensis infection.

Purpose of the Study:

  • To investigate the structural plasticity of mucosal nerves in the rat jejunum during Nippostrongylus brasiliensis infection.
  • To understand the dynamic changes in mucosal nerve density and morphology during inflammation and recovery.

Main Methods:

  • Nematode infection model (Nippostrongylus brasiliensis) in rats.
  • Histological analysis of jejunal mucosal nerves at different time points postinfection.
  • Quantification of nerve density and number per villus.

Main Results:

  • Rat jejunal mucosal nerves undergo remodeling, with degenerative and regenerative phases.
  • A net increase in mucosal nerve density and number per villus was observed seven weeks postinfection.
  • These findings indicate structural plasticity of mucosal nerves in inflamed intestinal tissues.

Conclusions:

  • Intestinal mucosal nerves exhibit significant structural plasticity in response to inflammation.
  • Nerve remodeling impacts the interaction between the enteric nervous system and other mucosal components during parasitic infections.
  • Understanding these neuro-immune interactions is crucial for disease pathogenesis and therapeutic strategies.

Related Experiment Videos