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The movement of solutes and cells across tight junctions
J L Madara1, C Parkos, S Colgan
1Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
Annals of the New York Academy of Sciences
|January 1, 1992
Abstract:
The TJ is a highly dynamic rate-limiting barrier for passive transepithelial solute flow. It is not only physiologically regulated but is modulated in various disease states as well. Such modulations occur as a result of epithelial cell interactions with immune cells or immune cell products and thus epithelial barrier function appears to be regulated in disease states.