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Published on: November 14, 2017
Study of apolipoprotein E genetic polymorphism in patients with atherosclerotic cerebral infarction
Ben-yan Luo1, Zhi Chen, Feng Chen
1Department of Neurology, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310003, China. lobenyan@263.net
Objective:
To explore the frequency and significance of ApoE gene polymorphisms in Chinese patients with atherosclerotic cerebral infarction (ACI).
Methods:
Polymerase chain reaction and gene sequencing, single nucleotide polymorphisms of ApoE gene were used to analyze 33 cases of patients with ACI and 35 controls.
Results:
The frequencies of ApoE gene single nucleotide polymorphisms 465C/G, 462C/G and 451delC in the ACI group were significantly higher than those in the control group (P<0.05). The prevalence of polymorphism 486G/T in the control group was significantly higher than that in the ACI group (P=0.011).
Conclusions:
465C/G,462C/G and 451delC polymorphisms might be associated with ACI.486GT allele might have protective effect on the pathogenesis of ACI.
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