Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Structural and ultrastructural data on human cutaneous lipids].

M Haftek1

  • 1U.346 Inserm/CNRS, peau humaine et immunité, hôpital Edouard-Herriot, 69437 Lyon, France. haftek@lyon.inserm.fr

Pathologie-Biologie
|October 22, 2003
PubMed
Summary

Intercellular lipids in the skin

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expression and ultrastructural localization of plasmin(ogen) in the terminally differentiated layers of normal human epidermis.

International journal of cosmetic science·2019
Same author

[The epidermal barrier].

Annales de dermatologie et de venereologie·2018
Same author

Fragility of epidermis in newborns, children and adolescents.

Journal of the European Academy of Dermatology and Venereology : JEADV·2016
Same author

Percutaneous absorption of benzophenone-3 loaded lipid nanoparticles and polymeric nanocapsules: A comparative study.

International journal of pharmaceutics·2016
Same author

Measurement, analysis and prediction of topical UV filter bioavailability.

International journal of pharmaceutics·2014
Same author

'Memory' of the stratum corneum: exploration of the epidermis' past.

The British journal of dermatology·2014

Area of Science:

  • Skin biology and barrier function
  • Lipid self-assembly and organization
  • Epidermal homeostasis and desquamation

Context:

  • The stratum corneum's intercellular spaces host self-assembling lipid bilayers.
  • Lipid organization influences the movement of hydrophilic components.
  • This movement affects the accessibility of corneodesmosomes to enzymes.

Purpose:

  • To elucidate the role of intercellular lipids in epidermal barrier function.
  • To understand how lipid organization impacts epidermal desquamation.
  • To investigate the relationship between lipid structure and enzyme accessibility.

Summary:

  • Intercellular lipids in the stratum corneum form a barrier regulating water loss.
  • Lipid self-assembly drives the displacement of hydrophilic materials towards intercellular junctions.
  • This process influences corneodesmosome accessibility to extracellular enzymes, affecting skin shedding.

Impact:

  • Findings provide insights into skin barrier mechanisms.
  • Understanding lipid dynamics can inform treatments for skin barrier disorders.
  • This research highlights the importance of lipid composition in epidermal health.

Related Experiment Videos