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Related Experiment Videos

Extraocular muscles are spared in advanced Duchenne dystrophy.

H J Kaminski1, M al-Hakim, R J Leigh

  • 1Department of Neurology, Department of Veterans Affairs Medical Center, Cleveland, OH 44106.

Annals of Neurology
|October 1, 1992
PubMed
Summary

Saccadic eye movement velocities were normal in patients with Duchenne's or Becker's muscular dystrophy, suggesting extraocular muscles are protected from degeneration.

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Area of Science:

  • Neurology
  • Ophthalmology
  • Muscular Dystrophy Research

Background:

  • Duchenne's and Becker's muscular dystrophy primarily affect fast-twitch extremity muscle fibers.
  • Saccades, rapid eye movements, are typically mediated by fast-twitch fibers.
  • A decrease in saccadic velocity was hypothesized in patients with these muscular dystrophies.

Purpose of the Study:

  • To investigate ocular motility in patients with Duchenne's and Becker's muscular dystrophy.
  • To determine if saccadic velocities are affected in advanced stages of these conditions.
  • To assess the integrity of extraocular muscle function.

Main Methods:

  • Infrared oculography was utilized to measure saccadic peak velocities.
  • The study included 3 patients with advanced Duchenne's or Becker's muscular dystrophy.

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  • Clinical assessments were performed on an additional 7 patients.

    • Main Results:

    • Peak velocities of saccades in patients with advanced Duchenne's or Becker's muscular dystrophy were found to be normal.
    • Clinical examinations of other patients with these dystrophies also yielded normal findings.
    • This is the first study to examine ocular motility in these conditions.

    Conclusions:

    • Extraocular muscle function is preserved in Duchenne's and Becker's muscular dystrophy.
    • Fast-twitch fibers in extraocular muscles may possess protective properties against degeneration.
    • Ocular motility remains intact despite peripheral muscle fiber degeneration.