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Endothelial cell activation in inflammation: lessons from mutant mouse models.

Christopher G. Kevil1

  • 1Department of Pathology, LSU Health Science Center, 1501 Kings Hwy, 71130, Shreveport, LA, USA

Pathophysiology : the Official Journal of the International Society for Pathophysiology
|October 22, 2003
PubMed
Summary

Inflammation

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Area of Science:

  • Cardiovascular inflammation and endothelial cell biology.

Background:

  • Inflammatory response dysregulation contributes to cardiovascular diseases.
  • The vascular endothelium plays a key role in regulating inflammation.

Purpose of the Study:

  • To review the role of the endothelium in inflammation.
  • To discuss insights from gene-targeted mutant mouse studies.

Main Methods:

  • Review of literature on endothelial inflammation.
  • Analysis of findings from gene-targeted mutant mouse models.

Main Results:

  • Endothelial adhesion and signaling molecules are implicated in cardiovascular disease pathogenesis.
  • Gene-targeted studies reveal complex roles of endothelial pathways in inflammatory diseases.

Conclusions:

  • Understanding endothelial dysfunction in cardiovascular disease requires further research.
  • Gene targeting, including Cre-loxP systems, aids tissue-specific investigation but has limitations.

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