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Related Experiment Videos

Autonomic nervous system function in multiple sclerosis.

A J McDougall1, J G McLeod

  • 1Department of Neurophysiology, Liverpool Hospital, University of New South Wales, Liverpool NSW 2170, Australia.

Journal of the Neurological Sciences
|October 22, 2003
PubMed
Summary
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Autonomic dysfunction is common in multiple sclerosis (MS), affecting over half of patients. These changes, particularly cardiovascular and sudomotor issues, correlate with increased MS severity and disability.

Area of Science:

  • Neurology
  • Autonomic Neuroscience
  • Clinical Medicine

Background:

  • Autonomic dysfunction significantly impacts multiple sclerosis (MS) patients, causing disability.
  • While bladder, bowel, and sexual dysfunction are documented, cardiovascular and sudomotor changes are less understood.
  • Previous research highlights the need for comprehensive assessment of autonomic nervous system involvement in MS.

Purpose of the Study:

  • To investigate autonomic symptoms and test results in multiple sclerosis (MS) patients.
  • To correlate autonomic function test abnormalities with clinical MS features.
  • To explore the prevalence and clinical significance of cardiovascular and sudomotor autonomic dysfunction in MS.

Main Methods:

  • Evaluated 63 multiple sclerosis (MS) patients for autonomic symptoms.

Related Experiment Videos

  • Conducted cardiovascular and sudomotor autonomic function tests.
  • Correlated autonomic test results with MS clinical severity and patient-reported symptoms.

    • Main Results:

    • Autonomic symptoms were prevalent, linked to increased MS severity.
    • Over half of MS patients showed abnormalities in at least one autonomic function test (excluding bladder, GI, sexual).
    • Autonomic dysfunction (≥2 abnormal tests) affected 18% of patients and correlated with higher MS severity; parasympathetic cardiovascular abnormalities occurred in 16% and were associated with increased MS severity.

    Conclusions:

    • Cardiovascular and sudomotor autonomic abnormalities are common in MS and associated with increased disease severity.
    • Autonomic dysfunction in MS likely results from brainstem and spinal cord lesions affecting regulatory pathways.
    • While varied, autonomic test abnormalities generally have minor clinical significance, except for postural hypotension.