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[Sensitivity of the pathogen of Campylobacter infection to various antibiotics]
Abstract:
Antibiotic sensitivity of 21 Campylobacter strains isolated from humans, monkeys and birds with diarrhea was assayed and the findings are presented. It was shown that all the isolates were highly sensitive to ofloxacin, pefloxacin, ciprofloxacin, josamycin, pipemidinic acid and amoxyclav (a combination of amoxycillin and clavulanic acid). The predominating majority of the strains were resistant to rifampicin, amoxycillin and phosphomycin. The majority of the cultures were sensitive to erythromycin and roxithromycin while some of the isolates were resistant to them which could be used as an additional biological characteristic of Campylobacter cultures and considered in choosing agents for antibiotic therapy.
Insights
This study assessed antibiotic sensitivity in 21 Campylobacter strains from various sources. Most strains were sensitive to fluoroquinolones and macrolides but resistant to amoxicillin and rifampicin.
Area of Science:
- Microbiology
- Infectious Diseases
- Veterinary Medicine
Background:
- Campylobacter species are significant causes of bacterial gastroenteritis in humans and animals.
- Understanding antibiotic resistance patterns is crucial for effective treatment and public health.
Purpose of the Study:
- To determine the antibiotic sensitivity profiles of Campylobacter strains isolated from diarrheal cases in humans, monkeys, and birds.
- To identify effective antibiotics for treating Campylobacter infections and inform therapeutic strategies.
Main Methods:
- Isolation and identification of 21 Campylobacter strains from clinical samples.
- Antibiotic sensitivity testing using standard microbiological assays.
Main Results:
- All isolates demonstrated high sensitivity to ofloxacin, pefloxacin, ciprofloxacin, josamycin, pipemidinic acid, and amoxyclav.
- Predominant resistance was observed against rifampicin, amoxycillin, and phosphomycin.
- Majority sensitivity to erythromycin and roxithromycin, with some resistant strains noted.
Conclusions:
- Fluoroquinolones and certain other antibiotics are effective against these Campylobacter strains.
- Resistance to amoxicillin and rifampicin is common, necessitating careful selection of antibiotics.
- Antibiotic sensitivity patterns can serve as a biological marker for Campylobacter and guide treatment choices.