Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cognitive functioning as a predictor of ischemic stroke incidence.

Suzana Alves de Moraes1, Moyses Szklo, Kate Tilling

  • 1Department of Epidemiology, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA. mszklo@jhsph.edu

Epidemiology (Cambridge, Mass.)
|October 22, 2003
PubMed
Summary

Cognitive impairment did not predict ischemic stroke in younger adults within the Atherosclerosis Risk in Communities (ARIC) study. These findings differ from studies in older populations, suggesting age may influence the cognitive impairment-stroke link.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Healthcare utilization and morbidity preceding a dementia classification: the Atherosclerosis Risk in Communities (ARIC) study.

BMC health services research·2026
Same author

Factors influencing accelerated progression in behavioral variant frontotemporal dementia.

Journal of neurology·2026
Same author

Developing a platform protocol for clinical trials evaluating interventions that target proposed mechanisms of Long COVID: RECOVER-VITAL.

Clinical trials (London, England)·2026
Same author

Dissecting the effect of long-term exposure to air pollution on risk of dementia in UK Biobank.

Environmental health : a global access science source·2025
Same author

Acute effects of daylight saving time clock changes on mental and physical health in England: population based retrospective cohort study.

BMJ (Clinical research ed.)·2025
Same author

An epigenome-wide analysis of DNA methylation, racialized and economic inequities, and air pollution.

Clinical epigenetics·2025

Area of Science:

  • Neuroscience
  • Epidemiology
  • Cardiovascular Research

Background:

  • Previous research suggests a link between cognitive impairment and increased stroke risk.
  • The Atherosclerosis Risk in Communities (ARIC) study explored this association in a cohort of middle-aged adults.

Purpose of the Study:

  • To investigate whether cognitive impairment predicts future ischemic stroke incidence.
  • To examine the relationship between cognitive function and stroke risk in a younger population.

Main Methods:

  • A cohort of 11,958 individuals aged 48-67 was followed from 1990-1997.
  • Cognitive performance was assessed using three tests: Delayed Word Recall, Digit Symbol, and Word Fluency.
  • Incident strokes were identified through hospital records, death certificates, and follow-up surveys.

Related Experiment Videos

Main Results:

  • No consistent association was found between cognitive test scores and ischemic stroke incidence after adjusting for confounders.
  • Hazard ratios for the lowest vs. highest cognitive quartiles ranged from 1.0 to 1.5, with wide confidence intervals, indicating no significant predictive value.

Conclusions:

  • The study did not replicate the association between cognitive impairment and stroke incidence observed in older populations.
  • The lack of association in this cohort may be due to the younger age of participants or differences in cognitive assessment tools.