Related Experiment Video
Updated: Jan 24, 2026

Isolation and Characterization of Neutrophil-derived Microparticles for Functional Studies
Published on: March 2, 2018
[Experimental study of the effect of sodium nitrate on the functional neutrophil and macrophage activity]
V P Deriagina1, Iu V Mashkovtsev, A P Il'nitskiĭ
1Cancer Research Center, Russian Academy of Medical Sciences, Moscow 115478, Kashirskoe Shosse.
Abstract:
The impact of sodium nitrite on functional activity of macrophages and neutrophiles of the abdominal cavity and blood of mice BALB/c was investigated in vitro and in vivo experiments. Functional activity was estimated according to formation of oxygen active forms. It was shown that sodium nitrite significantly inhibits formation of reactive oxygen species released from mouse peritoneal neutrophiles and macrophages, when they are being activated in vitro. Sodium nitrite was given in water at concentration 500.0 mg/l mice for 210 days immunodepression action was revealed which expressed reduction by leukopoes and decrease functional activity of blood neutrophils. Under the same conditions nitrite did not effect on functional activity of resident peritoneal macrophages.
More Related Videos
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
07:28Isolation, Purification and Labeling of Mouse Bone Marrow Neutrophils for Functional Studies and Adoptive Transfer Experiments
Published on: July 10, 2013
Related Concept Videos
Serum Studies: Renal Function Tests
Electrophilic Aromatic Substitution: Nitration of Benzene
Antianginal Drugs: Nitrates and β-Blockers
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
Regulation of Sodium and Potassium
Sodium Regulation
Sodium ions make up approximately 90% of extracellular cations, with a normal blood plasma concentration of 136–148 mEq/L. A decrease in blood volume and pressure triggers the release of renin from granular cells in the juxtaglomerular complex (JGC), primarily...
Roles of Electrolytes: Sodium and Potassium
Antiepileptic Drugs: Sodium Channel Blockers
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...