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[Oncologic risk factors in papillomavirus infection]
N R Safronnikova1, M I Zaraĭskiĭ, A B Chukhlovin
1N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, I.P. Pavlov State Medical University, St. Petersburg.
Abstract:
Cytological screening is essential for adequate diagnosis of gynecological cancer. Moreover, every effort should be made to identify such risks of cancer as viruses (HPV, Herpes simplex, cytomegalovirus, Epstein-Barr virus, etc.). When high risk HPV-16 and HPV-18 are detected, diagnostic strategies should include assay of blood prolactin and prolactin/TTH ratio. Virus-related tumors and various risk groups may be studied using HPV genotyping detection of high-risk alleles of certain genes. Hence, some HPV gene variants and gene polymorphism can be investigated as potential risk factors in women.