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Methylene blue for the treatment and prophylaxis of ifosfamide-induced encephalopathy

A R Turner1, C D Duong, D J Good

  • 1Department of Medical Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada.

Clinical Oncology (Royal College of Radiologists (Great Britain))
|October 23, 2003
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DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...