Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gain control from beyond the classical receptive field in primate primary visual cortex.

Ben S Webb1, Chris J Tinsley, Nick E Barraclough

  • 1School of Psychology, University of Nottingham, University Park, Nottingham NG7 2RD, UK. bsw@psychology.nottingham.ac.uk

Visual Neuroscience
|October 23, 2003
PubMed
Summary

Visual gain control in the brain is modulated by surrounding stimuli. Optimal suppression occurred when surround grating orientation matched the neuron

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development and validation of a domain-specific scale of founder characteristics associated with startup success.

PloS one·2026
Same author

Exploring the methodological quality and risk of bias in 200 systematic reviews: A comparative study of ROBIS and AMSTAR-2 tools.

Research synthesis methods·2026
Same author

Performance of an AI-powered visualization software platform for precision surgery in breast cancer patients.

NPJ breast cancer·2024
Same author

Perceptual discrimination of action formidableness and friendliness and the impact of autistic traits.

Scientific reports·2024
Same author

TRP-2 / gp100 DNA vaccine and PD-1 checkpoint blockade combination for the treatment of intracranial tumors.

Cancer immunology, immunotherapy : CII·2024
Same author

Inter-subject correlation of audience facial expressions predicts audience engagement during theatrical performances.

iScience·2024

Area of Science:

  • Neuroscience
  • Visual System Processing
  • Computational Neuroscience

Background:

  • Gain control is crucial for visual information processing.
  • Heeger's model proposed normalization by a broad population of neurons in primary visual cortex (V1).
  • This gain control manifests as changes in a V1 neuron's semisaturation constant.

Purpose of the Study:

  • To investigate how flanking and annular gratings modulate gain in V1 neurons.
  • To determine the effect of surround stimuli orientation on V1 neuronal gain.
  • To understand the mechanisms of gain control beyond the classical receptive field.

Main Methods:

  • Experiments conducted on anesthetized marmosets (Callithrix jacchus).
  • Presented flanking and annular gratings of varying orientations.

Related Experiment Videos

  • Fitted the Michaelis-Menten equation to response-contrast functions.

    • Main Results:

    • Surround stimuli modulate V1 neuronal gain via divisive suppression.
    • Response gain was maximally reduced when surround grating orientation matched the preferred orientation.
    • Surround suppression strength was consistent across retinal eccentricity and laminar distribution.

    Conclusions:

    • Gain control in marmoset V1 is influenced by surround stimuli orientation.
    • Feedback from extrastriate areas likely mediates long-range gain control.
    • Findings align with observations in macaque visual systems.