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Buccal delivery systems.

Jinsong Hao1, Paul W S Heng

  • 1Department of Pharmacy, National University of Singapore, Singapore.

Drug Development and Industrial Pharmacy
|October 23, 2003
PubMed
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Buccal drug delivery offers an easy way to administer medications, bypassing stomach issues and liver metabolism. This review covers the science, methods, and advancements in using the mouth for effective drug delivery.

Area of Science:

  • Pharmacology
  • Drug Delivery Systems
  • Oral Medicine

Background:

  • The oral cavity is a promising route for drug administration.
  • Buccal drug delivery avoids gastrointestinal degradation and first-pass metabolism.
  • It enables local or systemic drug effects.

Purpose of the Study:

  • To review the advantages and limitations of buccal drug delivery.
  • To describe the anatomical structure of the oral mucosa.
  • To outline methodologies for evaluating buccal drug delivery systems.

Main Methods:

  • Literature review focusing on physiology, pharmacology, and pathology.
  • Analysis of formulation design in buccal delivery.
  • Examination of recent developments in the field.

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Main Results:

  • Buccal delivery presents unique benefits and challenges.
  • Understanding oral mucosa anatomy is crucial for effective delivery.
  • Evaluation methodologies integrate multiple scientific disciplines.

Conclusions:

  • Buccal drug delivery is a viable alternative route for various therapeutic applications.
  • Advancements in formulation and understanding of oral mucosa enhance its potential.
  • This review provides a comprehensive overview for researchers and formulators.