Jove
Visualize
Contact Us

Related Experiment Videos

A novel method of deriving the effect compartment equilibrium rate constant for propofol.

T A Lim1

  • 1Anaesthesiology Unit, Faculty of Medicine and Health Sciences, Universiti Putra, Malaysia. limta@hotmail.com

British Journal of Anaesthesia
|October 23, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The association between physical activity and burnout among anaesthesia postgraduate trainees in Malaysia.

The Medical journal of Malaysia·2022
Same author

Head and neck lumps in an Asian male.

The British journal of radiology·2011
Same author

Peri-operative blood pressure changes in normotensive and hypertensive patients.

The Medical journal of Malaysia·2008
Same author

Factors influencing post-operative hyperglycaemia in type 2 diabetes mellitus patients managed without intra-operative insulin.

The Medical journal of Malaysia·2006
Same author

Perceived skill and utilisation of information technology in medical education among final year medical students, Universiti Putra Malaysia.

The Medical journal of Malaysia·2006
Same author

BIS during etomidate-induced myoclonus.

Anaesthesia·2006
Same journal

Eye-tracking technology applied to regional anaesthesia task performance, safety and skill acquisition: a scoping review.

British journal of anaesthesia·2026
Same journal

Psychological factors associated with postoperative cognitive outcomes in older adults: reconciling adjusted effect estimates with P-value synthesis. Comment on Br J Anaesth 2026; 136: 1482-94.

British journal of anaesthesia·2026
Same journal

The long and winding road: a longitudinal study of UK anaesthetists in training.

British journal of anaesthesia·2026
Same journal

Association of cumulative fluid balance trajectories with haemodynamics, inflammation, and long-term mortality in critically ill patients with circulatory failure: bridging physiology and causal inference with target trial emulation. Comment on Br J Anaesth 2026; 136: 542-51.

British journal of anaesthesia·2026
Same journal

Risk of perioperative cardiorespiratory complications and mortality associated with preoperative glucagon-like peptide-1 receptor agonist use in type 2 diabetes mellitus. Comment on Br J Anaesth 2026; 136: 86-97.

British journal of anaesthesia·2026
Same journal

Hypotension and pulmonary atelectasis during general anaesthesia: a randomised crossover laboratory study.

British journal of anaesthesia·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

This study determined the propofol effect compartment equilibrium rate constant (keo) without EEG monitoring. The derived keo allows accurate prediction of propofol concentration at loss of consciousness.

Area of Science:

  • Pharmacology
  • Anesthesiology
  • Pharmacokinetics

Background:

  • Calculating propofol effect compartment concentration (Ce) in non-steady-state conditions necessitates the equilibrium rate constant (keo).
  • Traditional keo derivation for propofol relies on electroencephalogram (EEG) measurements.
  • This study explored an alternative method for determining keo.

Purpose of the Study:

  • To investigate an alternative method for deriving the equilibrium rate constant (keo) for propofol.
  • To determine if keo can be calculated without using electroencephalogram (EEG) monitoring.
  • To ensure consistent predicted effect compartment concentration (Ce) across different propofol administration methods.

Main Methods:

  • Seventy-five patients undergoing anesthesia induction received propofol via single bolus, infusion, or bolus-then-infusion.

Related Experiment Videos

  • Computer simulation was employed to predict central compartment concentration.
  • The keo was derived by ensuring the predicted Ce at loss of the eyelash reflex remained consistent across the three administration methods.

    • Main Results:

    • The derived keo was 0.80 min⁻¹.
    • The mean (SD) effect compartment concentration (Ce) at loss of the eyelash reflex was 2.27 (0.69) µg mL⁻¹.
    • Consistent Ce values were achieved at the pharmacodynamic endpoint regardless of administration method.

    Conclusions:

    • The effect compartment equilibrium rate constant (keo) can be determined without electroencephalogram (EEG) monitoring.
    • The propofol concentration at loss of the eyelash reflex can be accurately estimated using this alternative method.
    • This approach simplifies the determination of key pharmacokinetic parameters in anesthesia.