Standard therapy of Crohn's disease

Therapy of Crohn's disease is either counteracting the underlying mechanisms of bowel inflammation or specifically targeting certain complications of disease, e.g. strictures, fistulae, bacterial overgrowth, or anemia. The therapeutic arsenal is well defined and has been tested for safety and efficacy. There is need and opportunity to adapt therapies to individual situations. This is made on the basis of scientific facts that have been collected from randomized controlled trials and on the basis of reasoned thinking that weighs the potential effect against potential side effects in individual cases. In clinical practice, the potency of lifestyle changes such as smoking cessation is still underestimated and not extensively exploited. As the understanding of genetic mutations, their gene function and phenotypic expression grows, we anticipate that future treatment can be tailored to certain genotypes or phenotypes of Crohn's disease.