Related Experiment Video
Updated: Aug 30, 2026

Formulation of Vitamin A Tracer Doses for Administration to Human Subjects using Retinol Isotope Dilution Technique
Published on: March 31, 2026
25-hydroxyvitamin D levels among healthy children in Alaska
Bradford D Gessner1, Julia Plotnik, Pam T Muth
1Alaska Division of Public Health, PO Box 240249, 3601 C Street, Anchorage, AK 99524, USA. Brad_Gessner@health.state.ak.us
Insights
Vitamin D deficiency is common in Alaskan children, particularly those who are breastfed without adequate supplementation. This highlights a critical public health concern for infant nutrition in the region.
Area of Science:
- Pediatric Nutrition
- Public Health
- Vitamin D Metabolism
Background:
- Vitamin D deficiency is a growing concern in pediatric populations.
- The Women, Infants, and Children (WIC) program serves a vulnerable demographic.
- Geographic location, such as Alaska, may influence vitamin D levels due to limited sunlight exposure.
Purpose of the Study:
- To assess vitamin D levels in young children (6-23 months) enrolled in WIC programs in Alaska.
- To identify risk factors associated with low vitamin D levels in this population.
Main Methods:
- Cross-sectional study conducted in 2001-2002 involving 133 children from seven WIC clinics in Alaska.
- Data collection included a risk factor questionnaire and serum vitamin D level analysis.
- Children's ages ranged from 6 to 23 months.
Main Results:
- 11% of children had abnormal vitamin D levels (<15 ng/mL), and 20% had low-normal levels (15 to <25 ng/mL).
- Children who were exclusively breastfed showed a significantly higher risk of low vitamin D levels (RR=12 for <15 ng/mL, RR=3.6 for 15 to <25 ng/mL).
- Among breastfed children, only 34% received vitamin supplements, and 18% took them daily.
Conclusions:
- Vitamin D deficiency is prevalent among young children in Alaska.
- Breastfeeding without sufficient vitamin D supplementation is the primary risk factor for deficiency in this population.
- Public health initiatives should focus on improving vitamin D supplementation for breastfed infants in Alaska.
Objective:
To determine vitamin D levels among children 6 to 23 months old receiving services from Women, Infants, and Children (WIC) programs in Alaska. Study design During 2001 and 2002, we recruited 133 children receiving services at seven WIC clinics, administered a risk factor questionnaire, and collected blood.
Results:
Fifteen (11%) and 26 (20%) children, respectively, had vitamin D levels <15 (considered abnormal) and 15 to <25 ng/mL (low normal). Compared with other children, children who still breast-fed were more likely to have a vitamin D level <15 ng/mL (relative risk [RR], 12; 95% confidence interval [CI], 3.6-39) or 15 to <25 ng/mL (RR, 3.6; 95% CI, 1.9-6.8) than > or =25 ng/mL. Among 41 still breast-feeding children, 14 (34%) took supplemental vitamins, and six (18%) were reported to have received vitamins every day.
Conclusions:
Vitamin D deficiency is prevalent in Alaska. Breast-feeding in the absence of adequate vitamin D supplementation is the greatest risk factor.
Related Concept Videos
Role of Skin in Vitamin D Synthesis
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Skeleton and Calcium Homeostasis
