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Evolution of fibrin glue applicators.
1HAPTO Biotech Ltd, Jerusalem, Israel. gmarxxx@aol.com
Transfusion Medicine Reviews
|October 23, 2003
Summary
This review examines fibrin glue (FG) applicators, comparing the standard dual-syringe system with newer designs. It aims to improve FG device development for surgery and tissue engineering.
Area of Science:
- Biomaterials Science
- Surgical Technology
- Medical Device Development
Background:
- Fibrin glue (FG) is a vital surgical hemostatic and tissue adhesive used globally.
- The standard applicator relies on a dual-syringe system.
- Advancements are needed for improved surgical applications.
Purpose of the Study:
- To review the evolution of fibrin glue applicator designs.
- To analyze packaging and usability factors of commercial FG components.
- To propose a rating system for comparing applicator designs.
Main Methods:
- Review of patent literature on fibrin glue applicators.
- Analysis of various applicator technologies: mechanical, gas flow, gas pressure, electro-servo.
- Evaluation of packaging, assembly, and operational parameters.
Main Results:
- Development of dual-syringe systems and alternative designs.
- Discussion of packaging innovations to minimize needle use.
- Identification of key parameters: clogging, spray homogeneity, gas/vacuum needs, part count, and assembly time.
Conclusions:
- A proposed rating system allows objective comparison of FG applicator designs.
- The review aims to stimulate innovation in FG applicators and packaging.
- Improved devices are crucial for elective surgery, emergency care, and tissue engineering.