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Thread-like bridging strands: a morphologic feature present in all adenomatoid tumors
Ondrej Hes1, Delia M Perez-Montiel, Isabel Alvarado Cabrero
1Departments of Pathaolgy and Urology, Charles University Hospital Plzen, Czech Republic.
Annals of Diagnostic Pathology
|October 23, 2003
Summary
Thread-like bridging strands (TBS) are a consistent feature in adenomatoid tumors (ATs), regardless of patient gender or tumor location. These structures, formed by mesothelial cells, are highly specific to ATs.
Area of Science:
- Pathology
- Histology
- Oncology
Background:
- Adenomatoid tumors (ATs) are rare, benign neoplasms typically found in the genital tract.
- Histological examination reveals fibrous tissue separated by pseudotubular spaces.
- A characteristic feature is the presence of "thread-like bridging strands" (TBS) within these spaces.
Purpose of the Study:
- To investigate the frequency and diagnostic significance of TBS in a large series of adenomatoid tumors.
- To determine if TBS presence varies with tumor location or patient gender.
- To characterize the ultrastructural morphology of TBS.
Main Methods:
- Retrospective analysis of 69 adenomatoid tumor cases.
- Histopathological examination focusing on the presence and characteristics of TBS.
- Ultrastructural analysis of TBS morphology.
Main Results:
- Thread-like bridging strands (TBS) were identified in 100% of the studied adenomatoid tumors.
- The presence of TBS was consistent across all tumor locations and in both male and female patients.
- Ultrastructural analysis confirmed TBS are formed by the apposition of attenuated mesothelial cell cytoplasm.
Conclusions:
- Thread-like bridging strands (TBS) are a constant and defining morphologic feature of adenomatoid tumors.
- TBS are highly specific to adenomatoid tumors and are not observed in other epithelial structures.
- The consistent presence of TBS aids in the diagnosis of adenomatoid tumors, irrespective of gender or location.