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Updated: Aug 30, 2026

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease
Published on: May 22, 2026
[Value of Doppler indices of diastolic left ventricular dysfunction in acute cardiac insufficiency]
1Service de cardiologie, CH Aubagne, avenue des Soeurs Gastine 13400 Aubagne. sarques@ch-aubagne.rss.fr
Insights
Diastolic dysfunction is common in acute cardiac failure, regardless of ejection fraction. Doppler studies are crucial for diagnosis, though normal values don't always rule out diastolic insufficiency.
Area of Science:
- Cardiology
- Echocardiography
- Heart Failure
Background:
- Diastolic dysfunction is prevalent in stable heart failure with preserved systolic function.
- The prevalence of diastolic dysfunction in acute cardiac failure remains unknown.
Purpose of the Study:
- To determine the prevalence of diastolic dysfunction using Doppler studies in patients with acute cardiac failure.
- To assess the utility of mitral and pulmonary venous profiles, Vp, and Ea in diagnosing diastolic dysfunction in acute heart failure.
Main Methods:
- Doppler echocardiography was used to assess mitral and pulmonary venous flow, propagation velocity (Vp), and mitral annular velocity (Ea) in 28 patients with acute cardiac failure.
- Patients included those with preserved or altered systolic function, and varying ejection fraction.
Main Results:
- Diastolic dysfunction was observed in 95% (mitral profiles) and 100% (pulmonary profiles) of patients.
- Abnormal Vp or Ea values were found in 55% and 100% of patients, respectively.
- Combined indices E/Vp and E/Ea showed concordance with filling pressures in 83-100% of cases.
Conclusions:
- Diastolic dysfunction is nearly universal in acute cardiac failure, irrespective of ejection fraction.
- Normal Ea and Vp values do not exclude diastolic insufficiency in the acute setting.
Objective:
To examine the prevalence of diastolic dysfunction by Doppler study in acute cardiac failure.
Context:
A recent study showed that diastolic dysfunction is constant in stable cardiac failure with preserved systolic function and suggested that its measurement was not necessary for the diagnosis of diastolic cardiac failure, but the prevalence of diastolic dysfunction in acute cardiac failure is not known.
Method:
The mitral and pulmonary venous profiles, the propagation velocity Vp of colour filling flow, and the lateral velocity Ea of the mitral ring in DTI were studied at the time of treatment initiation in 28 patients in sinus rhythm and in acute cardiac failure (11 NYHA IV and 17 with pulmonary oedema), of whom 18 had an ejection fraction greater than 50%.
Results:
Diastolic dysfunction was present in the combined study of mitral and pulmonary profiles in 95% and 100% respectively of patients in cardiac failure with preserved systolic function and altered systolic function, and Vp < 45 and/or Ea < 8 cm/s was observed in 55% and 100% respectively of these patients. At respective pathological threshold values of 1.5 and 10, the combined indices E/Vp and E/Ea were concordant with the evaluation of filling pressures in 83% of patients with preserved systolic function and 100% of the systolic cardiac failure cases.
Conclusion:
Diastolic dysfunction is almost constant in acute cardiac failure independently of the ejection fraction value. However, normal values of Ea and Vp do not exclude the diagnosis of diastolic cardiac insufficiency in the acute situation.
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