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Ionic liquid as a suitable phase for multistep parallel synthesis of an array of isoxazolines
Manuela Rodriquez1, Alessandro Sega, Maurizio Taddei
1Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via A. Moro, 53100 Siena, Italy.
Organic Letters
|October 24, 2003
Abstract:
[reaction: see text]. A parallel array of isoxazoline diamides was prepared using an ionic liquid [bmim][BF4] as the phase where a three-step procedure (Schotten-Baumann, 1,3-dipolar cycloaddition, ester amidation with Me3Al) was carried out. At the end, selective extraction of the final products with diethyl ether allowed simple isolation of the 16 components of the array (Syncore technology).