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Published on: March 8, 2019
[Expression and location of heme oxygenase in the lung of experimental cirrhotic rats]
1Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Objectives:
To observe the function of heme oxygenase (HO) in the lung damage in hepatic cirrhosis rats.
Methods:
Liver cirrhosis model rats were made by CCl4. Lung samples taken from normal and cirrhotic rats were examined for HO-1 and HO-2 protein and expression distribution with immunohistochemical staining and western blot.
Results:
Liver cirrhosis model rats were successfully constructed. There was a notable increase of HO-1 staining (0.062+/-0.021 vs 0.185+/-0.044, t=11.24, P<0.01) and protein expression (0 vs 5294.92+/-46.02, t=11.45, P<0.01) in both vascular and bronchial smooth muscle cells and endothelium in cirrhotic rats, however, no statistical difference of HO-2 between cirrhotic and normal rats was observed.
Conclusion:
The HO-CO pathway is probably involved in the pathogenesis of lung damage in hepatic cirrhosis rats.
