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[Antiphospholipid syndrome updating].

Juan Antonio Orts1, Angel Zúñiga, María Orera

  • 1Unidad de Autoinmunidad, Area de Diagnóstico Biológico, Hospital de la Ribera, Alzira, Valencia, España. jaorts@hospital-ribera.com

Medicina Clinica
|October 24, 2003
PubMed
Summary

Antiphospholipid syndrome (APS) involves blood clots and pregnancy loss due to antiphospholipid antibodies. This review covers APS diagnosis, causes, manifestations, and current treatment strategies.

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Area of Science:

  • Immunology
  • Hematology
  • Obstetrics

Context:

  • Antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity in the presence of antiphospholipid antibodies.
  • Despite its known prevalence, many APS cases remain undiagnosed, highlighting a gap in clinical recognition.
  • APS presents with diverse clinical manifestations affecting multiple organ systems, necessitating multidisciplinary management.

Purpose:

  • To provide an updated overview of antiphospholipid syndrome (APS).
  • To review current diagnostic criteria, underlying molecular mechanisms, and clinical features of APS.
  • To summarize contemporary management and treatment approaches for APS.

Summary:

  • This review synthesizes recent literature on antiphospholipid syndrome (APS), detailing diagnostic criteria, molecular basis, and clinical manifestations.
  • It addresses the challenges in managing APS, including the lack of evidence-based guidelines for standard therapies like antiplatelet and anticoagulation drugs.
  • The review also discusses individualized treatment strategies based on thrombosis or fetal loss risk, offering a state-of-the-art perspective.

Impact:

  • Enhances understanding of APS etiology and pathophysiology, areas still not well understood.
  • Aims to improve diagnosis and management of APS, potentially reducing recurrent thrombotic events and pregnancy loss.
  • Provides a foundation for evidence-based treatment strategies, guiding clinicians across various specialties in managing APS patients.

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