Allergy to asticot maggots. Identification of allergens

Area of Science:

• Allergology
• Immunology
• Entomology

Background:

• Allergic reactions to Asticot larvae (maggots) have been anecdotally reported in anglers and occupationally exposed individuals.
• This study investigates the specific allergens responsible for hypersensitivity reactions in a 12-year-old male with respiratory symptoms after contact with Asticot maggots.

Observation:

• Skin prick tests with Asticot extract were positive in the patient but negative in controls.
• Specific IgE antibodies against Asticot were detected in the patient's serum.
• SDS-PAGE and IgE immunoblotting identified a 60 kDa protein band as the primary allergen.

Findings:

• A 60 kDa protein was identified as the main allergen in Asticot maggots responsible for the patient's allergic response.
• Nasal challenge testing confirmed an immediate hypersensitivity reaction with a significant increase in nasal resistance.
• This is the first report characterizing the specific allergens involved in Asticot hypersensitivity.

Implications:

• Asticot maggots should be considered a potential cause of respiratory allergic symptoms in anglers.
• The findings suggest a type I hypersensitivity mechanism is involved in Asticot hypersensitivity.
• Further research into insect-derived allergens is warranted for occupational and recreational exposure risks.