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Related Experiment Videos

Blood pressure variability during 120-day head-down bed rest in humans.

M Shiraishi1, T Kamo, S Nemoto

  • 1Division of Neurology, Department of International Medicine, School of Medicine, St. Marianna University, 2-16-1, Sugao, Miyamae-ku, Kawasaki City, Kanagawa-Pre 216-8511, Japan. shira@marianna-u.ac.jp

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|October 24, 2003
PubMed
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Physical inactivity during head-down bed rest (HDBR) affects blood pressure rhythms. Circadian rhythms were maintained, but systolic blood pressure amplitude decreased, indicating cardiovascular deconditioning.

Area of Science:

  • Cardiovascular Physiology
  • Space Medicine
  • Chronobiology

Background:

  • Physical inactivity and microgravity pose risks to cardiovascular health.
  • Understanding the impact on blood pressure rhythms is crucial for astronaut health.
  • Head-down bed rest (HDBR) simulates microgravity conditions.

Purpose of the Study:

  • To investigate the influence of prolonged physical inactivity and simulated microgravity on the periodic structure of blood pressure.
  • To analyze changes in systolic blood pressure (SBP) and heart rate (HR) rhythms during and after HDBR.

Main Methods:

  • Six healthy males underwent 120 days of HDBR.
  • Blood pressure and heart rate were monitored using portable sphygmomanometry and Holter electrocardiography.
  • Spectrum analysis was employed to assess circadian (approx. 24h), ultradian (approx. 12h), and shorter rhythms (approx. 8h).

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Main Results:

  • Circadian rhythm phases for SBP (24h, 12h, 8h) remained largely unchanged during HDBR.
  • Acrophase (peak time) of SBP showed a tendency to shift later in the day post-HDBR.
  • The amplitude of the 24-hour SBP rhythm tended to decrease during HDBR and significantly increased afterward, suggesting cardiovascular deconditioning.

Conclusions:

  • Circadian rhythms of SBP and HR can be maintained under simulated microgravity with controlled sleep-wake and feeding schedules.
  • A decrease in the 24-hour SBP amplitude during HDBR indicates rhythmic modulation related to cardiovascular deconditioning.
  • These findings highlight the need for countermeasures against cardiovascular deconditioning during long-duration space missions.