Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Estrogen-dependent inherited angioedema.

Karen E Binkley1, Alvin E Davis

  • 1Department of Medicine, Division of Clinical Immunology and Allergy, University of Toronto, Toronto, Canada. tbowen@pol.net

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|October 24, 2003
PubMed
Summary

Hereditary angioedema involves recurrent swelling episodes, often linked to C1 inhibitor deficiency. Androgens can increase C1 inhibitor levels and reduce attacks, offering a potential therapy for this condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiple Chemical Sensitivity/Idiopathic Environmental Intolerance: A Practical Approach to Diagnosis and Management.

The journal of allergy and clinical immunology. In practice·2023
Same author

Hereditary Angioedema in Pregnancy.

Obstetrical & gynecological survey·2021
Same author

Measurement of Bradykinin Formation and Degradation in Blood Plasma: Relevance for Acquired Angioedema Associated With Angiotensin Converting Enzyme Inhibition and for Hereditary Angioedema Due to Factor XII or Plasminogen Gene Variants.

Frontiers in medicine·2020
Same author

Human C1-Inhibitor Suppresses Malaria Parasite Invasion and Cytoadhesion via Binding to Parasite Glycosylphosphatidylinositol and Host Cell Receptors.

The Journal of infectious diseases·2015
Same author

Hereditary angioedema with normal C1 inhibitor function: consensus of an international expert panel.

Allergy and asthma proceedings·2013
Same author

The effect of C1 inhibitor on myocardial ischemia and reperfusion injury.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2012

Area of Science:

  • Immunology
  • Genetics
  • Endocrinology

Background:

  • Hereditary angioedema (HAE) presents with recurrent swelling episodes.
  • Biochemically, HAE is associated with reduced C1 inhibitor (C1-INH) levels or function.
  • Genetically, HAE is linked to mutations in the C1 inhibitor gene with autosomal dominant inheritance.

Purpose of the Study:

  • To explore the clinical effects of androgens and estrogens in hereditary angioedema patients.
  • To investigate the mechanisms underlying sex steroid hormone influence on C1 inhibitor protein levels.
  • To understand the pathogenesis and treatment of both classic and estrogen-dependent angioedema.

Main Methods:

  • Clinical observation of hereditary angioedema patients.
  • Biochemical analysis of C1 inhibitor levels and function.

Related Experiment Videos

  • Genetic analysis of C1 inhibitor gene mutations.
  • Review of hormonal therapy effects, including androgens and estrogens.

    • Main Results:

    • Androgens demonstrate a therapeutic effect by increasing C1 inhibitor protein levels.
    • Androgen administration is associated with a reduction in angioedema attacks.
    • Estrogens may have an antagonistic effect on C1 inhibitor protein levels.

    Conclusions:

    • Androgens represent an important therapeutic strategy for hereditary angioedema by modulating C1 inhibitor levels.
    • The mechanisms of sex steroid hormone action in HAE remain largely unknown.
    • A novel estrogen-dependent form of angioedema may provide insights into hormone-related HAE pathogenesis and treatment.