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Synthesis and relative binding affinity to human steroid receptors of substituted 3-aryloxycoumarins
Robert Bakhchinian1, François Terrier, Serge Kirkiacharian
1Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie de PARIS-SUD, 5 rue Jean-Baptiste Clément, F-92296 Cedex, Chatenay Malabry, France.
Abstract:
The synthesis of a set of substituted 3-aryloxycoumarins was performed. The study of the relations between their structure and their relative binding affinity to human androgen, progesterone, alpha and beta estrogen receptors was achieved.
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