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Quinine-induced cutaneous vasculitis.

E J Price1, J S Bevan, A Rees

  • 1Department of Medicine, University Hospital of Wales, Cardiff.

The British Journal of Clinical Practice
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

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Severe cutaneous vasculitis is a rare, life-threatening complication of quinine sulphate, often prescribed for nocturnal cramps. This case highlights the potential dangers of this widely used drug.

Area of Science:

  • Pharmacology
  • Dermatology
  • Toxicology

Background:

  • Quinine sulphate is frequently prescribed for nocturnal leg cramps despite limited evidence from controlled trials.
  • Adverse reactions to quinine sulphate are generally considered uncommon.

Observation:

  • A 60-year-old woman developed severe cutaneous vasculitis three weeks after initiating quinine sulphate (300 mg nightly).
  • The patient's condition was fatal despite treatment with immunosuppressive agents like prednisolone and cyclophosphamide.

Findings:

  • Cutaneous vasculitis is a rare but potentially fatal adverse effect associated with quinine sulphate therapy.
  • This report reviews three prior cases, supporting the association between quinine and vasculitis.

Implications:

Related Experiment Videos

  • Clinicians should be aware of the risk of severe cutaneous vasculitis when prescribing quinine sulphate.
  • Further investigation into the safety profile and efficacy of quinine for nocturnal cramps is warranted.