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Related Experiment Videos

Androgen receptor CAG repeat polymorphism is associated with cognitive function in older men.

Kristine Yaffe1, Emily R Edwards, Li-Yung Lui

  • 1Department of Psychiatry, University of California, San Francisco 94121, USA.

Biological Psychiatry
|October 24, 2003
PubMed
Summary

Longer CAG repeat lengths in the androgen receptor gene are linked to poorer cognitive function in older men. Further research is needed to understand this association and potential testosterone treatments.

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Area of Science:

  • Neuroscience
  • Genetics
  • Gerontology

Background:

  • Androgen receptors are present in brain regions crucial for learning and memory.
  • CAG repeat length polymorphism in the androgen receptor gene may affect androgen sensitivity.
  • Longer CAG repeats are associated with reduced androgen sensitivity.

Purpose of the Study:

  • To investigate the association between CAG repeat length polymorphism in the androgen receptor gene and cognitive function in older men.

Main Methods:

  • Study included 301 community-dwelling white men (mean age 73.0 +/- 7.1).
  • CAG repeat length polymorphism in the androgen receptor gene was analyzed.
  • Cognitive performance was assessed using three standardized cognitive tests.

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Main Results:

  • Greater CAG repeat length correlated with lower scores on all three cognitive tests (p <.05).
  • Cognitive impairment was observed in 9.8% of men with low CAG repeat length versus 16.3% in higher tertiles (OR=1.8).

Conclusions:

  • A significant association exists between androgen receptor gene CAG repeat length and cognitive function in older men.
  • Further research should elucidate the underlying mechanisms.
  • Investigating testosterone's role in preventing cognitive decline is warranted.