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Renal effects of growth hormone. II. Electrolyte homeostasis and body composition
G D Ogle1, A R Rosenberg, G Kainer
1Department of Nephrology, Prince of Wales Children's Hospital, Randwick, Sydney, Australia.
Abstract:
Growth hormone (GH), either directly or through insulin-like growth factor-1 (IGF-1), has a wide spectrum of physiological and renal effects. This review concentrates on the effects of GH (derived from either pituitary or recombinant technology) and IGF-1 in three main areas: (1) sodium and water homeostasis; (2) calcium and phosphate balance, bone density and interactions with mineral regulating hormones; (3) fat and lean body mass. Observations of physiological changes in states of GH deficiency and excess in humans and animal models are presented. The lack of long-term toxicological data indicates that GH treatment for short stature in non-GH deficient children, with or without renal disease, should proceed with caution.
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