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Updated: Aug 30, 2026

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres
Published on: November 5, 2016
Sugar coating extends half-lives and improves effectiveness of cytokine hormones
1Vanderbilt University and Veterans Affairs Medical Center, 777 Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37232-6307, USA. mark.koury@vanderbilt.edu
Abstract:
Recombinant human erythropoietin (rhEPO) is an effective and widely used therapeutic agent that is produced by bioengineering. Modification of the rhEPO protein by glycoengineering increased its already abundant N-glycosylation, which enhances its erythropoietic activity in vivo by decreasing its metabolic clearance. Elliott et al. recently reported increased in vivo activities of thrombopoietin (Mpl ligand) and leptin following carbohydrate addition to both, which suggests that such glycoengineering could be applied to a variety of hormones, cytokines and growth factors.
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