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Updated: Aug 30, 2026

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products
Published on: April 6, 2015
Differences in host susceptibility to disease progression in the human challenge model of Haemophilus ducreyi
Stanley M Spinola1, Cliffton T H Bong, Andrew L Faber
1Departments of Medicine, Indiana University, Indianapolis, Indiana 46202, USA. sspinola@iupui.edu
Abstract:
With human volunteers inoculated at two sites with Haemophilus ducreyi, outcomes for a subject were not independent. In a reinfection trial, 2 of 11 previous pustule formers and 6 of 10 previous resolvers resolved all sites of infection. There was no correlation between serum bactericidal or phagocytic activity and outcome in the trial. These data indicate that different hosts are differentially susceptible to disease progression versus resolution in the model.

