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Severe asthma.

Nicholas J Kenyon1, Nizar N Jarjour

  • 1Division of Pulmonary and Critical Care Medicine, University of California, Davis, Davis, CA, USA. njkenyon@ucdavis.edu

Clinical Reviews in Allergy & Immunology
|October 24, 2003
PubMed
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Severe asthma involves persistent symptoms and declining lung function despite treatment. Research is exploring genetic, environmental, and infectious causes, alongside advanced diagnostic and management strategies for better control.

Area of Science:

  • Pulmonology
  • Allergy and Immunology

Background:

  • Severe asthma is defined by refractory, difficult-to-control symptoms, reduced quality of life, and accelerated lung function decline.
  • Pathologic changes in severe asthma involve airways and lung parenchyma, but their individual contributions are unclear.
  • Genetics, environmental factors, and infections are under investigation for their role in severe asthma development.

Purpose of the Study:

  • To review the current understanding of severe asthma, including its phenotype, evaluation, and management.
  • To highlight the complexity of severe asthma involving multiple compartments of the lung.
  • To emphasize the need for comprehensive evaluation and management strategies.

Main Methods:

  • Review of existing literature on severe asthma.

Related Experiment Videos

  • Discussion of clinical evaluation including associated conditions and advanced diagnostic tools.
  • Overview of current management principles.

    • Main Results:

    • Severe asthma is characterized by persistent symptoms and functional decline despite therapy.
    • Associated conditions like GERD, VCD, and rhinosinusitis warrant investigation.
    • Advanced diagnostics and a comprehensive approach are crucial for management.

    Conclusions:

    • Severe asthma requires a multifaceted approach considering genetics, environment, and lung pathology.
    • Integrated diagnostic and therapeutic strategies are essential for improving patient outcomes.
    • Combination anti-inflammatory and bronchodilator therapy remains central to management.