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A novel mouse-friendly cognitive task suitable for use in aging studies.

David A Blizard1, Laura Cousino Klein, Rachel Cohen

  • 1Center for Developmental and Health Genetics, Pennsylvania State University, University Park, PA 16802, USA. dab22@psu.edu

Behavior Genetics
|October 24, 2003
PubMed
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A novel "return to home cage" reward procedure effectively motivates mice in cognitive tests. This animal-friendly method matches traditional food rewards, avoiding confounds in aging and cognition research.

Area of Science:

  • Neuroscience
  • Animal Behavior
  • Cognitive Psychology

Background:

  • Cognitive tests in mice often use deprivation or aversive stimuli.
  • These methods may confound results, especially when comparing young and old animals due to aging effects on maze performance.

Purpose of the Study:

  • To test a novel reward procedure for motivating maze learning in mice.
  • To provide an animal-friendly alternative to traditional motivational techniques.

Main Methods:

  • Food- and water-satiated mice from two genetically heterogeneous groups were used.
  • Mice learned a Lashley III maze, with reward being access to their home cage upon reaching the goal box.

Main Results:

  • Mice motivated by "return to home cage" learned the maze as quickly as those motivated by hunger and food reward.

Related Experiment Videos

  • This indicates the home cage return is an effective reinforcer for maze learning.

    • Conclusions:

    • "Return to home cage" is a viable and effective reinforcer for cognitive tests in mice.
    • This method offers an animal-friendly, economical alternative that avoids confounding effects of deprivation and aversive stimuli, particularly relevant for aged mice.