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Updated: Aug 30, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

[Hyperhomocysteinemia in acute cerebral infarction]

Rebeca O Millán-Guerrero1, Clemente Vázquez, Lizette Isais-Aguilar

  • 1Servicio de Neurología, Clínica HGZ UMF 1 IMSS, Colima.

Gaceta Medica De Mexico
|October 25, 2003
PubMed

Insights

Elevated homocysteine levels were found in 59% of patients with acute cerebral infarction. This study did not find a link between high homocysteine and common risk factors for stroke.

Area of Science:

  • Neurology
  • Cardiovascular Science
  • Metabolic Disorders

Context:

  • Hyperhomocysteinemia is increasingly implicated in the arteriosclerotic processes underlying cerebral infarction.
  • Understanding homocysteine's role in stroke is crucial for developing targeted interventions.

Purpose:

  • To quantify plasmatic homocysteine levels in patients experiencing acute cerebral infarction.
  • To investigate potential associations between homocysteine levels and clinical stroke subtypes or known risk factors.

Summary:

  • This descriptive study analyzed 22 patients with acute cerebral infarction, measuring serum homocysteine levels.
  • Elevated homocysteine was detected in 59% of patients (13 out of 22), with an average level of 20.68 mumol/l.
  • No significant correlation was identified between hyperhomocysteinemia and clinical stroke characteristics or traditional risk factors like hypertension, diabetes, smoking, or alcoholism.

Impact:

  • The findings highlight a high prevalence of hyperhomocysteinemia in acute cerebral infarction patients.
  • Further research is needed to elucidate the specific factors contributing to elevated homocysteine and to develop strategies for its reduction.
  • Lowering homocysteine levels may offer a novel approach to mitigating cerebrovascular disease incidence.
Abstract

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