[Neuroblastoma: epidemiology, pathomorphological and molecular diagnosis, prognosis]

Neuroblastoma is the third most common neoplasm of childhood. About 70% of cases occurs by 5 years old and around 95% cases in the patients younger than 10 years old. Neuroblastoma is part of the spectrum of the family neuroblastic tumors. The family consists of heterogeneous group of tumors, difficult to classify. Additionally some cases of neuroblastoma show tendency to self-maturation and regression. The family consists of neuroblastoma (NB), ganglio-neuroblastoma (GNB) and ganglineuroma (GN). In recent years there has been considerable development in the classification concepts from purely histological to clinico-pathological one. These schemes include clinical, pathological and molecular features od tumors which allow more accurate prognostication.