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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

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Published on: June 13, 2014

Targeted delivery of biologic and other antineoplastic agents

G Rowlinson-Busza1, A A Epenetos

  • 1Department of Clinical Oncology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.

Current Opinion in Oncology
|December 1, 1992
PubMed

Insights

Researchers are exploring new ways to deliver cancer drugs directly to tumors, minimizing harm to healthy tissues. Strategies include advanced antibody therapies, targeted drug activation, and liposome carriers for more effective cancer treatment.

Area of Science:

  • Oncology
  • Immunology
  • Pharmacology

Background:

  • Targeted delivery of antineoplastic agents aims to improve efficacy and reduce side effects.
  • Monoclonal antibodies are key for targeted therapy, with ongoing research into enhancing their capabilities.

Purpose of the Study:

  • To review current strategies for targeted delivery of antineoplastic agents to tumor cells.
  • To discuss improvements in immunotargeting and novel drug delivery systems.

Main Methods:

  • Review of existing literature on targeted cancer therapy strategies.
  • Discussion of advancements in monoclonal antibody-based therapies, including immunotoxins and bifunctional antibodies.
  • Exploration of antibody-enzyme conjugates for prodrug activation and liposome-based drug delivery.

Main Results:

  • Monoclonal antibodies are central to targeted therapy, with improvements focusing on novel radioisotopes, cytokines, linkers, and drug potency.
  • Bifunctional antibodies show promise in radioimmunotherapy and targeted immunotherapy by activating cytotoxic cells.
  • Prodrug activation via antibody-enzyme conjugates and liposomes offer strategies to reduce systemic chemotherapy toxicity.

Conclusions:

  • Multiple innovative strategies are being investigated to enhance the targeted delivery of antineoplastic agents.
  • These advancements in targeted therapy, including antibody engineering and novel drug carriers, hold significant potential for improving cancer treatment outcomes and patient safety.

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