Isolation and characterization of new epothilone analogues from recombinant Myxococcus xanthus fermentations
Courtney M Starks1, Yiqing Zhou, Fenghua Liu
1Kosan Biosciences, Inc., 3832 Bay Center Place, Hayward, California 94545, USA.
Journal of Natural Products
|October 25, 2003
Abstract:
Nine new epothilone analogues (6-8, 10, 11a, 11b, 12, 13, and 15) were isolated from fermentations of Myxococcus xanthus strains engineered with modified polyketide synthase genes. The epothilone structures were elucidated primarily through interpretation of 1D and 2D NMR data. 4-Desmethyl-10,11-didehydroepothilone D (6) displayed activity against several tumor cell lines, including a multi-drug-resistant cell line.
